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Deferasirox: Uses & Side Effects

    Deferasirox is an iron chelator used to treat chronic iron overload caused by blood transfusions. Also used in patients with non-transfusion-dependent thalassemia syndromes, and in patients with elevated liver iron concentration and serum ferritin. Deferasirox is sold under the brand name Exjade & Asunra (in injectable form) & Oleptiss (Tablet formulation) both by Novartis among others.

    Uses of Deferasirox

    • Deferasirox binds to iron and removes it from the bloodstream.
    • Deferasirox is used to treat iron overload caused by blood transfusions in adults and children at least 2 years old.
    • Deferasirox is also used to treat chronic iron overload syndrome caused by a genetic blood disorder in adults and children who are at least 10 years old.
    • Deferasirox may also be used for purposes not listed in this medication guide.

    Side Effects

    More common:

    • Diarrhea
    • dizziness
    • earache or pain in the ear
    • nausea
    • stomach pain
    • voice changes
    • vomiting

    Rare:

    • Blindness
    • blurred vision
    • change in hearing
    • change in vision
    • pain or discomfort in the eye

    Incidence not known:

    • Black, tarry stools
    • bleeding gums
    • blood in the urine or stools
    • dark urine
    • decrease in the amount of urine
    • general feeling of tiredness or weakness
    • hives, welts, skin rash
    • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
    • light-colored stools
    • lower back or side pain
    • pale skin
    • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    • redness, soreness, itching of the skin
    • sores, blisters
    • stomach pain, continuing
    • unusual bleeding or bruising
    • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
    • vomiting of blood or material that looks like coffee grounds
    • yellow eyes or skin

    Warnings

    You should not use deferasirox if you have severe kidney or liver disease, advanced cancer, a blood cell or bone marrow disorder, or low levels of platelets in your blood.

    Deferasirox can harm your liver or kidneys. Call your doctor at once if you have swelling, shortness of breath, pain in your upper stomach, loss of appetite, little or no urinating, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

    Deferasirox may also cause stomach or intestinal bleeding. Call your doctor at once if you have symptoms of stomach bleeding such as bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

    SOURCE

    Disclaimer

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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